PARIS - A cold chill circulated around Maria Sharapova as the title holder was frozen out of the French Open on Monday but there was no stopping Novak Djokovic and Rafa Nadal from blazing a trail towards a scorching showdown.

Lucie Safarova of the Czech Republic (L) celebrates after defeating Maria Sharapova of Russia during their women's singles match during the French Open tennis tournament at the Roland Garros stadium in Paris, France, June 1, 2015. [Photo/Agencies]

A day after rain played havoc with the schedule, Sharapova's hopes of reaching a fourth successive final at Roland Garros were turned to dust in the fourth round by the dynamite forehand of Lucie Safarova, the Czech winning 7-6(3) 6-4.

An explosive quarter-final, however, awaits those lucky enough to hold Wednesday tickets for Court Philippe Chatrier after nine-times champion Nadal and world number one Djokovic set up a smoking showdown that former champion Jim Courier called "the match of the season so far."

For 10 days now, all roads at Roland Garros had been leading to this last eight collision and it became a reality as Spanish sixth seed Nadal tamed American tyro Jack Sock 6-3 6-1 5-7 6-2 shortly before Djokovic overwhelmed Richard Gasquet 6-1 6-2 6-3.

For under-the-weather Sharapova, though, Monday was a total let down.

The Russian spent the changeovers coughing and spluttering into a tissue but the second seed refused to blame health problems for her earliest Paris exit since 2010.

"I'm still a competitor no matter what. I'm going to do everything in order to go out and give it my best. I did the best I could. Today it wasn't enough, because my opponent had a different gear than I did," the 2012 and 2014 champion told reporters.

Sharapova was one of eight grand slam champions in action on day nine with Serena Williams and Roger Federer making sure they did not suffer the same fate as the Russian.

Top seed Williams relied on her famed survival instincts rather than her explosive firepower to extinguish the challenge of fellow American Sloane Stephens 1-6 7-5 6-3.

As she came back from a set down for a third match in a row, her exertions turned her hot-pink outfit into darker shade of cerise -- but that mattered little to the fashion-conscious Williams.

"I keep fighting, I never give up," a grinning Williams summed up following a performance strewn with 43 unforced errors.

Fellow 33-year-old Federer also harbours hopes of landing another title in Paris.

In the build-up to his showdown with French showman Gael Monfils, Federer tweeted a squiggly sketch of the Eiffel Tower.

While his attempt at drawing the famous Paris landmark would not look out of place in the sketch books of his five-year-old twins Charlene Riva and Myla Rose, what the Swiss produced on court was a masterpiece.