Protesters hold up a mock coffin as they take part in a demonstration in Caracas February 12, 2014. [Photo/Agencies]

CARACAS - An anti-government protest by the Venezuelan opposition turned violent Wednesday, killing one person and injuring several others.

The protestors, mostly students, started their demonstrations peacefully for about two hours before they resorted to rocks, sticks and tear gas when confronting with the police.

A government official confirmed that a supporter of President Nicolas Maduro was dead during the violence, with 23 others injured.

However, Venezuelan opposition leader Maria Corina Machado said two opposition protesters were killed.

The police said they arrested 30 protestors, with five police vehicles burnt and some government offices vandalized in violence.

The protest was held as part of "Youth Day" celebration, which marks the participation of students in a 19th century independence battle against colonial rules.

The opposition has also held some protests around the country in the last two weeks to protest against the government.

It was the worst bout of unrest in Venezuela since turmoil after President Nicolas Maduro's election last year.

The violence was a crescendo to weeks of sporadic demonstrations in the provinces led by opposition hardliners who denounce Maduro for failing to control inflation, crime and product shortages and vow to push him from office.

The government says the opposition is sowing violence to stage a coup similar to the one a decade ago that briefly ousted late socialist leader Hugo Chavez, though there are few signs that the current melees could topple Maduro.

The country's top prosecutor confirmed the death of a student and a pro-government community leader amid chaotic scenes as marches by opposition and government sympathizers ended just a few blocks apart in the city center.

Maduro said another student suffered serious brain damage and was in critical condition after being shot in the head.

"This violent group had failed until now in their attempts to fill Venezuela with death and blood," Maduro said in a speech outside Caracas to commemorate an independence-era battle.

"Today we lament the death of two young Venezuelans."

Twenty-three people were injured, 25 arrested, four police vehicles burnt, and some government offices vandalized in violence throughout the day, officials said.

The mayor of stridently opposition municipality of Chacao, in the east of the city, said on Twitter that a third person had been shot dead in his district.

Social networks quickly fell into a familiar pattern of recriminations, with both sides blaming the other based on little clear information about what had happened.

Opposition activists said armed government supporters belonging to hardline groups known as "colectivos" had fired on the peaceful march. Government officials pinned the deaths on "fascists" who they said had planned violence from the start.