Republican US presidential nominee Donald Trump holds up signs at the end of a campaign rally in Lakeland, Florida, US, October 12, 2016. [Photo/Agencies]

Though he had so far not rescinded his endorsement of Trump, House Speaker Ryan on Monday told fellow Republican lawmakers in a conference call that he would neither defend nor campaign with Trump.

After top Republican leaders either distanced themselves from or abandoned their bellicose standard-bearer after his leaked lewd women comments, Trump on Tuesday unleashed vitriol at Republican party establishment.

"Disloyal R's (Republicans) are far more difficult than Crooked Hillary. They come at you from all sides," said Trump on Twitter. "They don't know how to win - I will teach them!"

In other posts on Tuesday, Trump called House Speaker Paul Ryan "very weak and ineffective leader" and Senator John McCain "very foul mouthed" who "begged for my support during his primary."

Trump also proclaimed in one post that "shackles have been taken off" him and he could now "fight for Americans the way I want to."