Chief government officials should resign if serious vaccine violations occurred in their jurisdictions, according to a revised regulation approved by the State Council, China's Cabinet, ahead of National Children's Inoculation Day, which fell on Monday.

The revision of the previous regulation on the management of vaccines was made after a scandal involving 570 million yuan ($88 million) worth of Category 2 vaccines that had been stored improperly and sold across China.

Category 2 vaccines are considered optional.