Anna made her first trip to China in Oct. 1925, during which she visited Beijing, Shanghai and Guangzhou, and met with Feng Yuxiang, Soong Qing-ling and other famous figures. In June of 1927, she visited China for the second time, and she witnessed the failure of the KMT-CPC cooperation. Later she went to Shanghai,Wuhan and Changsha and other cities to report what was happening in China. She interviewed many leaders of Chinese labor and women's movements. The following year, her book " China's Millions" was published in the United Sates, telling the world about the situation in China. It made a considerable impact on the world.

After the War of Resistance Against Japanese Aggression broke out, Anna made a 10-day trip to the anti-Japanese base areas in January 1938, during which she interviewed several high-ranking military officers including Zhu De, Liu Bocheng, He Long and others. Based on what she had learned in China, she wrote the book "One-Fifth of Mankind", which was published in July the same year. The book told the world about the situation of the anti-Japanese national united front in China, and sang the praise of the great anti-Japanese war of aggression by the Chinese people. In 1940,She journeyed to China for the fourth time, during which she held in-depth talks with Zhou Enlai for several times in Chongqing.

In early 1941, the "Southern Anhui Incident" happened. Her wrote news stories for the newspapers in New York to tell the truth about the incident and exposed Jiang Kai-shek's plot to undermine the anti-Japanese national united front. On 6th July 1946, she flied to Shanghai and began her fifth trip to China. In an interview with Mao Zedong in Yan'an on Aug. 6, she had the chance to listen to Mao's famous thesis "All Reactionaries Are Paper Tigers". In January 1948, upon the invitation of the national conference on American policy towards China, she made a keynote speech on "the realities in China". Afterwards, she made speeches on several occasions to appeal to the American government to change its policy of supporting Jiang Kai-shek. In December, her new book "Dawn Comes Up Like Thunder Out of China: An Intimate Account of the Liberated Areas in China was published", It was a book themed on her visit to Yan'an.

In early 1958, she visited new China upon the invitation of the Chinese government. On 1st Oct, she was invited to mount the Tian'anmen Rostrum on the National Day to attend the rally in celebration of the 9th anniversary of the founding of new China, and Mao Zedong cordially received her on the rostrum. In 1959, Anna joined the Chinese and foreign journalists visiting group to Tibet. In Tibet, she visited many places and interviewed local Tibetans, and wrote two books, "Tibetan Interviews" and "When Serfs Stood Up in Tibet". In February 1962, she established the journal "Letters from China", through which she told American people and the people of the rest of the world about what she heard and saw in new China in the form of letters. The journal published 69 issues until she passed away. On 29th March 1970, Anna died of illness in Beijing and was buried in the Babaoshan Revolutionary Martyrs' Cemetery.