Guiyang has established friendship city or friendly exchange relationships with 32 cities worldwide, engaging in extensive exchanges and cooperation in areas such as culture and tourism, environmental preservation, youth exchanges, and urban governance. Since the start of the 14th Five-Year Plan (2021-25) period, the city has added 15 new sister cities. Additionally, it has established close trade relations with over 211 countries and regions worldwide.

Guiyang Longdongbao International Airport has opened 15 international and regional passenger routes to destinations like Bangkok, Singapore, Hong Kong, and Macao, along with seven international cargo routes. It is also a designated port for the 240-hour visa-free transit policy, allowing travelers from 54 countries, including the United States, United Kingdom, Russia, Japan, and South Korea, to stay visa-free for up to 10 days with a connecting ticket.

Guiyang warmly invites cultural and tourism entrepreneurs, creative planners, and content creators from around the world to explore its landscapes and culture, allowing the world to feel the charm of "Cool Guiyang".