日批在线视频_内射毛片内射国产夫妻_亚洲三级小视频_在线观看亚洲大片短视频_女性向h片资源在线观看_亚洲最大网

Global EditionASIA 中文雙語Fran?ais
China

Brain network dysfunction central to Parkinson's disease identified

By WANG XIAOYU | China Daily | Updated: 2026-02-12 00:00
Share
Share - WeChat

Researchers led by Beijing's Changping Laboratory have identified a specific brain network whose dysfunction appears central to Parkinson's disease, a finding that helps explain how existing treatments work and points to more precise, less invasive therapies.

The study, published in Nature on Thursday, identifies the somatocognitive action network, or SCAN — a system that coordinates whole-body movement — as critically impaired in Parkinson's patients. Among those with the disease, SCAN becomes abnormally hyperconnected to several deep-brain structures.

Parkinson's disease is a progressive neurological disorder that affects movement, sleep, mood and overall quality of life. There is no cure, and current treatments focus on symptomatic relief. China has more than five million Parkinson's patients, accounting for more than 43 percent of the global total.

An international team led by Changping Laboratory, in collaboration with Peking University, Tsinghua University, Washington University in St. Louis and Harvard University, analyzed imaging data from 863 individuals.

The researchers found that in Parkinson's patients, SCAN shows excessive connectivity to subcortical regions, including the substantia nigra — where dopamine-producing neurons degenerate — as well as to all known targets for deep brain stimulation.

The study found that existing Parkinson's treatments — from oral medications to surgical interventions — share a common mechanism: reducing this pathological hyperconnectivity. As connectivity normalizes, patients' symptoms tend to improve.

"SCAN hyperconnectivity appears central to Parkinson's pathophysiology, and its reduction is a hallmark of successful neuromodulation," the study said. It added that precisely targeting SCAN nodes could enhance current therapies and pave the way for novel, minimally invasive treatments.

Building on the findings, Chinese researchers developed a noninvasive brain circuit modulator designed to target the SCAN network. Results from a clinical trial involving 36 patients showed the approach was twice as effective as traditional motor region stimulation, achieving a response rate of 55.5 percent.

Liu Hesheng, a professor at Changping Laboratory and senior author of the study, said as of late November, more than 100 patients in China and overseas had been treated with the device.

One patient, an elderly woman surnamed Hu, experienced fewer falls and improvements in independent walking, swallowing and speech after one course of treatment. After three years of biannual sessions, she reduced her medication by more than half, significantly lowered her risk of motor complications and regained the ability to manage daily activities independently. She is now considering traveling abroad.

Liu stressed the importance of early intervention efforts in neurodegenerative diseases, before extensive neuron loss makes recovery unlikely.

"While patients may hesitate to undergo invasive surgery in the early stages, this noninvasive therapy offers a viable option to intervene earlier and more precisely," he said.

Ren Jianxun, a scientist at Changping Laboratory and first author of the study, said the device has received a Class 2 medical device registration license. "We aim to obtain the highest Class 3 certification by conducting further clinical trials in the coming years," he said.

Today's Top News

Editor's picks

Most Viewed

Top
BACK TO THE TOP
English
Copyright 1994 - . All rights reserved. The content (including but not limited to text, photo, multimedia information, etc) published in this site belongs to China Daily Information Co (CDIC). Without written authorization from CDIC, such content shall not be republished or used in any form. Note: Browsers with 1024*768 or higher resolution are suggested for this site.
License for publishing multimedia online 0108263

Registration Number: 130349
FOLLOW US
主站蜘蛛池模板: 国产精品8 | 精品国产一区二区三区在线观看 | 在线成人日韩 | 成人女同av免费观看 | 麻豆网址 | 青青青视频在线 | 成人黄色在线免费观看 | 国产成人97精品免费看片 | 中文字幕日韩在线观看 | 国产精品综合网 | 调教驯服丰满美艳麻麻在线视频 | 国产精品自拍网 | 免费国产视频 | 久草五月 | 日韩天堂在线 | 欧美日韩亚洲在线观看 | 少妇特黄a一区二区三区 | 免费黄色小说视频 | 影音先锋一区 | 成人精品一区二区三区中文字幕 | 自拍av在线 | 日韩不卡高清 | 日韩美女中文字幕 | 成人av动漫在线观看 | 日韩欧美视频在线播放 | 五月婷婷狠狠干 | 国产v片在线观看 | 国产69精品久久久久久 | 日韩av综合 | 成人午夜免费福利视频 | aaa一区二区| 69精品久久久久久 | 国产精品久久久久永久免费看 | 国产美女激情视频 | 日韩精品播放 | 国产视频1区2区 | 欧美男人天堂网 | 久久久国产免费 | 欧美一区二区在线播放 | 一区二区视频在线播放 | 五月深爱|