Real Madrid's Cristiano Ronaldo celebrates scoring their second goal with Marco Asensio during UEFA Champions League Quarter Final First Leg in Munich, Germany on April 12, 2017. [Photo/Agencies]

To make things worse for the hosts, Javi Martinez received his marching orders with 61 minutes played as he saw his second yellow card of the night to weaken his team.

Real capitalized on their numerical advantage and sealed the deal in the 77th minute when Ronaldo wrapped up his brace after slotting home Marco Asensio' s cross to become the first player who reached 100 goals in an UEFA club competition.

The visitors could have reaped a higher victory but Bayern custodian Neuer denied Ronaldo as well as Benzema in the closing period with superb safes.

With the result, Real Madrid are in sight of their seventh straight semi-final, and they ended Bayern's 16-game winning streak on home soil.

"We played a very good first half. The second half is difficult to judge. We have to accept the defeat. Our first half performance gives us confidence for the second leg. We still have 90 minutes to play," Bayern coach Carlo Ancelotti said.

Bayern Munich will have to turn around the 2-1 loss at Real in the second leg on Tuesday.